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Published 11:58 21 Sept 2022 BST
Updated 12:23 21 Sept 2022 BST
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Mayweather was then asked if he would prefer the bout to be an exhibition or professional and said he is only interested in taking on opponents where he doesn't have a chance of being hurt.
He added: "I am not into fights where I am going to take any real punishment.
"So, guys like Conor McGregor and guys that don't really hit hard such as YouTubers or UFC guys, I don't really mind colliding with those kinds of individuals but nothing where I am going to put myself in a position where I am going to harm myself or hurt myself."
The 45-year-old officially ended his career after beating the Irishman - with a 100 per cent win record of 50 wins in 50 fights - while McGregor has endured a contrasting spell in his career.
McGregor has lost three of his last four fights in the UFC but hasn't fought since breaking his leg in his fight against Dustin Poirier in July, 2021.
However the larger than life character signalled his intentions to return to the ring when attending the Monaco Grand Prix earlier this year.
He said: Boxing is my first love in combat sports. I had such a great time the last time I was out there.
"Obviously, my return will be in the octagon for UFC - that story is far from over, in fact it's just being written, it is just the beginning. But, boxing, for sure I will grace the squared circle again in the future."
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