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Published 22:49 13 Jan 2018 GMT
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Ant’s spokesperson confirmed to the Sun On Sunday that the TV presenter was "very sad to announce" that he is ending his marriage.
It was added: "Ant asks for privacy at this difficult time, for both himself, Lisa and their immediate families. No further statement will be made."
The Sun On Sunday furthermore quotes a source who reveals that "this was a tough decision for Ant but he has to do the right thing for his health. "The marriage has effectively been struggling for eight months. He’s given it a good go."
Ms Armstrong is head of makeup for BBC's Strictly Come Dancing. Ant is known for his high-profile presenting gigs including I'm A Celebrity and Britain's Got Talent.
He is said to be worth around £62 million.
Ant entered rehab last summer for addiction to painkillers and the pair have recently been living apart. Still, Lisa took to Twitter as recently as November to deny that she and her husband were 'estranged'.
https://twitter.com/lisaAmakeup/status/947623943145443328
Prior to Ant travelling to the Aussie jungle for I'm A Celeb two months ago, a source told The Sun: "Ant is spending time apart from Lisa - he’s said he needs space and everyone respects that.
"They are effectively leading separate lives while he re-evaluates everything."
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